Serena Williams of the United States follows the ball during a quarterfinals match against Petra Kvitova of the Czech Republic at the All England Lawn Tennis Championships at Wimbledon, England, Tuesday, July 3, 2012. (AP Photo/Anja Niedringhaus)
Serena Williams reacts to a point against Zheng Jie during a third-round women's singles match at the All England Lawn Tennis Championships at Wimbledon, England, on Saturday, June 30, 2012. (AP Photo/Anja Niedringhaus)
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Serena Williams was down, then out of her match against Virginie Razzano after dropping a three-set decision in the French Open. Williams, who was seeking her 14th major title, had been 46-0 in first-round matches at Grand Slam tournaments before Tuesday's upset.
** FILE ** Tennis player Serena Williams poses at the Pan African Film & Arts Festival's opening-night premiere of Screen Gems' "Think Like a Man" in Los Angeles on Feb. 9, 2012. (AP Photo/Danny Moloshok)
Serena Williams waves after defeating Roberta Vinci of Italy, 6-2, 6-1, at the Sony Ericsson Open tennis tournament, Saturday, March 24, 2012, in Key Biscayne, Fla. (AP Photo/Lynne Sladky)
Serena Williams bounces her racket Jan. 23, 2012, during her fourth-round match against Ekaterina Makarova at the Australian Open in Melbourne, Australia. (Associated Press)
Serena Williams of the U.S. reacts in frustration during her fourth-round match against Russia's Ekaterina Makarova at the Australian Open in Melbourne, Australia, on Monday, Jan. 23, 2012. (AP Photo/Andrew Brownbill)
Serena Williams celebrates after defeating Greta Arn during their third-round match at the Australian Open, in Melbourne, Australia, Saturday, Jan. 21, 2012. (AP Photo/Andrew Brownbill)
Serena Williams defeated Tamira Paszek 6-3, 6-2 to claim her 15th consecutive match at Melbourne Park. Williams won the Australian Open in 2009 and 2010 but was injured last year. (Associated Press)
Serena Williams talks to the chair umpire Eva Asderaki during the women's championship match against Samantha Stosur of Australia at the U.S. Open tennis tournament in New York, Sunday, Sept. 11, 2011. (AP Photo/Mike Groll)
Samantha Stosur, of Australia, poses with the championship trophy after beating Serena Williams at the U.S. Open in New York on Sunday, Sept. 11, 2011. (AP Photo/Charles Krupa)
Serena Williams reacts after winning her semifinal match against Caroline Wozniacki of Denmark at the U.S. Open in New York on Saturday, Sept. 10, 2011. (AP Photo/Charlie Riedel)
Serena Williams reacts during her match against Ana Ivanovic of Serbia during the U.S. Open tennis tournament in New York, Monday, Sept. 5, 2011. (AP Photo/Mel Evans)