In this Dec. 13, 2020, photo, boxes containing the Pfizer-BioNTech COVID-19 vaccine are prepared to be shipped at the Pfizer Global Supply Kalamazoo manufacturing plant in Portage, Mich. The U.S. death toll from the coronavirus topped 300,000 Monday, Dec. 14, just as the country began dispensing COVID-19 shots in a monumental campaign to conquer the outbreak. (AP Photo/Morry Gash, Pool) **FILE**
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