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FILE- This May 1, 2018, file photo shows Merck corporate headquarters in Kenilworth, N.J. Merck posted a big fourth-quarter loss, mainly due to much higher spending on research, production and overhead, and announced longtime chief executive, Kenneth Frazier, will retire on July 1, 2021.  (AP Photo/Seth Wenig, File)

FILE- This May 1, 2018, file photo shows Merck corporate headquarters in Kenilworth, N.J. Merck posted a big fourth-quarter loss, mainly due to much higher spending on research, production and overhead, and announced longtime chief executive, Kenneth Frazier, will retire on July 1, 2021. (AP Photo/Seth Wenig, File)

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