CLEVELAND — Rookie Jake Moody missed a 41-yard field goal with six seconds left, leaving San Francisco stunned 19-17 by the Cleveland Browns, who ended the 49ers’ regular-season winning streak at 15 on Sunday and handed quarterback Brock Purdy his first loss as an NFL starter.
Dustin Hopkins kicked four field goals for the Browns (3-2) - the last with 1:40 left, capping a drive helped by a disputed unnecessary roughness call against San Francisco (5-1). Cleveland pulled off the league’s biggest upset this season without quarterback Deshaun Watson, who missed his second straight game with a bruised right shoulder.
The 49ers were short-handed without playmakers Christian McCaffrey and Deebo Samuel, who went out with injuries.
P.J. Walker came off Cleveland’s practice squad and outplayed Purdy, who had won his first 10 starts.
Purdy nearly pulled out a comeback, driving the 49ers into field-goal range in the final seconds before Moody pushed his attempt to the right.
Purdy was 12 of 27 for 125 yards and threw his first interception of the season.
JAGUARS 37, COLTS 20
JACKSONVILLE, Fla. — Trevor Lawrence threw two touchdown passes, Travis Etienne ran for a pair of scores as Jacksonville won its third straight and sent Indianapolis to its ninth straight road loss in the series.
The Jaguars (4-2) had their most lopsided victory of the season and this one was essentially over in the third quarter when Lawrence connected threw a 10-yard strike to rookie tight end Brenton Strange and put Jacksonville ahead 31-6. Lawrence also found Christian Kirk for a 29-yard TD in the second. Etienne scored on runs of 2 and 22 yards, also in the second.
The Colts (3-3) started Gardner Minshew in place of injured rookie Anthony Richardson. A sixth-round draft pick by the Jags in 2019, Minshew fumbled once and threw three interceptions.
Etienne gained 55 yards on 18 carries. Lawrence completed 20 of 30 passes for 181 yards, with the two TDs and an interception before hobbling off late after getting sacked. He had his left knee checked on the sideline.
Minshew completed 33 of 55 passes for 329 yards, with a touchdown to Josh Downs and the three picks.
TEXANS 20, SAINTS 13
HOUSTON — Rookie C.J. Stroud threw for 199 yards and two touchdowns and Houston got two defensive stops late seal the win over New Orleans and match the team’s win total of last season.
The Saints (3-3) trailed by 7 when Derek Carr threw a 51-yard pass to Rashid Shaheed to get them to the Houston 35. Five consecutive runs by Alvin Kamara got them to the 14. But Carr’s pass to Kamara on fourth-and-4 was short, giving Houston the ball with 4½ minutes left.
Houston (3-3) couldn’t move the ball after that and punted it back. New Orleans got to the Houston 24 on the next drive, but Carr’s throw on fourth-and-10 was intercepted by Steven Nelson with 21 seconds left to secure the win.
Carr threw for a season-high 353 yards and a touchdown as the Saints lost for the third time in four games after a 2-0 start. Kamara had 19 carries for 68 yards and Chris Olave had seven receptions for 96 yards.
Stroud was 13 for 27 and threw his first interception of the season after setting an NFL record of 191 attempts without a pick to start a career.
VIKINGS 19, BEARS 13
CHICAGO — Kirk Cousins threw for a touchdown, Jordan Hicks returned a fumble 42 yards for a score and Minnesota knocked Justin Fields out of the game in beating Chicago (1-5).
The Vikings (2-4) made just enough plays without injured star receiver Justin Jefferson and won for the second time in three games. Cousins completed 21 of 31 passes for 181 yards. T.J. Hockenson caught six passes for 50 yards.
Fields was sacked four times and exited with a right hand injury early in the third quarter. He finished 6 of 10 for 58 yards and an interception.
Rookie Tyson Bagent replaced field and got strip-sacked on Chicago’s next drive. Hicks returned it 42 yards for a TD, making it 19-6.
Bagent, undrafted out of Division II Shepherd University, finished a 77-yard drive by scoring from the 1. He was 10 of 14 with 83 yards in his debut.
DOLPHINS 42, PANTHERS 21
MIAMI — Tua Tagovailoa threw three touchdown passes to three different receivers as Miami rallied for the win and sent winless Carolina to its sixth straight loss.
Tagovailoa was 21 of 31 for 262 yards and has an NFL-leading 1,876 yards passing this season.
After trailing 14-0 early, Tyreek Hill put the Dolphins ahead with a 41-yard touchdown catch late in the second quarter. Hill caught six passes for 163 yards to bring his NFL-leading season total to 814 yards receiving. Jaylen Waddle added 51 yards on seven catches.
Miami (5-1) scored 35 straight points before Mike White replaced Tagovailoa with about four minutes left and threw an interception that was returned by cornerback Troy Hill for a touchdown.
Bryce Young finished 23 of 38 with 217 yards and was sacked four times for the Panthers (0-6).
Raheem Mostert had 17 carries for 115 yards and scored on runs of 1 and 4 yards, in addition to a 3-yard TD reception, after taking over as Miami’s lead ball carrier after rookie De’Von Achane wwas placed in injured reserve last week with a knee injury.
COMMANDERS 24, FALCONS 16
ATLANTA — Sam Howell threw three short passes for touchdowns and Washington intercepted Desmond Ridder three times in a win over Atlanta that ended a three-game skid.
Coming off a 40-20 home loss to the lowly Chicago Bears, the Commanders (3-3) redeemed themselves a bit against the Falcons (3-3).
Howell shook off five more sacks - he’s been dumped 34 times this season - to complete 14 of 23 passes for 151 yards. The Commanders (3-3), who showed more balance and ran for 72 yards, was led by their defense.
Kendall Fuller, Benjamin St-Juste and Jamin Davis had picks for Washington.
Ridder threw for 307 yards and a pair of scores. But it was the second time in three weeks that he’s had three turnovers in a game.
BENGALS 17, SEAHAWKS 13
CINCINNATI — Joe Burrow threw two early touchdown passes and Cincinnati intercepted Geno Smith twice in the second half, holding off Seattle for its second straight victory.
Burrow was 24 for 35 for 185 yards and an interception as the Bengals improved to 3-3 ahead of their bye week.
Cincinnati scored touchdowns on its first two possessions, but punted six times, giving Seattle the late chances.
The Bengals defense stopped Seattle in the red zone twice late to seal the win, the last time when Smith was hit by B.J. Hill and threw incomplete on fourth-and-8 on the Bengals 9 in the final minute.
Seattle (3-2) scored its only touchdown on the first drive of the game on Kenneth Walker’s 1-yard TD run. Smith was picked off twice in the second half. He finished 27 for 41 for 323 and was scrambling from the Cincinnati pass rush throughout.
RAVENS 24, TITANS 16
LONDON — Lamar Jackson threw a touchdown pass and Justin Tucker kicked six field goals in Baltimore’s win over Tennessee at Tottenham Hotspur Stadium.
Jackson mostly shined in his international debut, but Tucker stole the spotlight by going 6 for 6, with the longest just 41 yards. Jackson was 21 of 30 for 223 yards and he led the team with 62 yards on the ground.
The Ravens (4-2) got plenty of chunk plays on offense and a 70-yard punt return by Devin Duvernay, but several of their drives stalled deep in Tennessee territory. Rookie receiver Zay Flowers scored his first NFL TD.
Tennessee (2-4) quarterback Ryan Tannehill limped off after the third quarter, replaced by Malik Willis. Tannehill, who was moving gingerly after a hit from Justin Madubuike in third quarter, finished 8 of 16 for 76 yards. Willis was 4 for 5 for 74 yards.
Derrick Henry scored on a 15-yard run in the third quarter and finished with 97 yards on 12 carries.
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